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TEKA
Komisji Nauk Medycznych V/2017.
Commission of Medical Sciences
Spis treści - plik PDF
Redakcja - plik PDF
OVER THE COUNTER DRUGS COMMON GOOD? PART 1. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS- pełny artykuł (full article) - plik PDF
Hanna Koszel1*, Zofia Danilczuk**, Halina Szymczyk**
*1Student Research Group, Department of Experimental and Clinical Pharmacology,
Medical University of Lublin, 8b Jaczewskiego Str., 20-090 Lublin, Poland,
**Department of Experimental and Clinical Pharmacology, Medical University of Lublin,
8b Jaczewskiego Str., 20-090 Lublin, Poland
*Corresponding author e-mail: malgoknap@gmail.com
S u m m a r y.The use of Over The Counter Drugs (OTCs) in Poland is constantly increasing. Poland ranks third regarding the sale of OTC drugs in Europe. The most common OTC medications are pain relievers, anti-inflammatory drugs and cold and cough remedies. People are unaware of the dangers associated with OTC drugs misuse. Taking OTC medications without consulting a doctor first puts people at higher risk for adverse effects which include drug-drug and drug-food interactions, side effects and overdose.
K e y w o r d s: cOver The Counter Drugs, self-medication, interactions, safety
OVER THE COUNTER DRUGS COMMON GOOD? PART 2. MOST COMMONLY USED OTC DRUGS- pełny artykuł (full article) - plik PDF
Hanna Koszel*, Zofia Danilczuk**, Halina Szymczyk**
1Student Research Group, Department of Experimental and Clinical Pharmacology, Medical University of Lublin,
8b Jaczewskiego Str., 20-090 Lublin, Poland,
2Department of Experimental and Clinical Pharmacology, Medical University of Lublin,
8b Jaczewskiego Str., 20-090 Lublin, Poland,
S u m m a r y. Self-medication, a phenomenon observed all over the world, is closely related to easy public access to Over-The-Counter drugs (OTCs) available on the market. First of all, taking OTCs without consulting a health care professional may cause a number of dangerous adverse effects associated with taking too many medications simultaneously, including dietary supplements. The paper discusses OTC drug-drug and drug-food interactions.
K e y w o r d s: Over-The-Counter Drugs, self-medication, interactions, safety
THE ROLE OF MAJOR MARIJUANA CONSTITUENTS IN PSYCHOTIC DISORDERS- pełny artykuł (full article) - plik PDF
Izabela Banaszkiewicz, Grażyna Biała, Marta Kruk-Słomka
Department of Pharmacology and Pharmacodynamics,
Medical University of Lublin, 4A Chodki Str.,
20-093 Lublin, Poland
S u m m a r y. Activation of the endocannabinoid system (ECS) in the brain leads to modulation of the excitatory and inhibitory neurotransmitters release, and has been strongly suggested to participate in neuropsychiatric disorders. Cannabis consumption is related to an increased risk of psychosis development due to psychomimetic compound, i.e. tetrahydrocannabinol (THC). Studies have found that another cannabis component, cannabidiol (CBD) might have antipsychotic effects in schizophrenia, mainly through enhancement of endocannabinoid signalling. The paper discusses the role of the ECS in developing psychotic disorders based on currently available results of animal and human experimental, epidemiological, imaging, and clinical studies. The authors review several research articles on the subject available from PubMed database.
K e y w o r d s: cannabis, schizophrenia, marijuana, psychosis, THC, CBD
NANOTECHNOLOGY - NEW TREND IN COSMETOLOGY? pełny artykuł (full article) - plik PDF
Magdalena Kołodziejczyk*, Mateusz Reda**, Anna Bogucka-Kocka*
Chair and Department of Biology and Genetics, Medical University of Lublin, 4A Chodki Str.,
20-093 Lublin, Poland
Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland
S u m m a r y. Nanoparticles used in cosmetic preparations and drugs used on the skin are probably capable of overcoming the skin barrier. Titanium oxide (IV) easily overcomes this barrier without penetrating the deeper layers of the skin. It is possible to accumulate nanoparticles in the hair follicles [14]. In addition, nanoparticles can cause inflammation and damage to animal tissues [2]. As a result of exposure to nanomaterials, oxidative stress in the body can be triggered. This may result in the formation of free radicals and their pathological impact on the body [27]. A precautionary matrix has been introduced in the European Union. Its aim is to increase responsibility in applying the precautionary method. It facilitates the identification of probable sources of risk when using nanoparticles [3].
K e y w o r d s: nanoparticles, nanotechnology, liposomes, nanoemulsion, nanometals
ART THERAPY THROUGH NONREPRESENTATIONAL ART: ABSTRACT PAINTING BY THE FEMALE RESIDENTS OF STROŃSKO VILLAGE.- pełny artykuł (full article) - plik PDF
Jadwiga Agata Kałużewska
The Institute of Ethnology and Cultural Anthropology University of Łód, 3/5 Lindleya Str., 90-131 Łód, Poland [extramural PhD]
S u m m a r y. The article discusses abstract painting workshop held in a small village of Strońsko, located in the Łód Province. The project had the character of an anthropological experiment using the language of contemporary art, far from any associations with Polish folk culture. The workshop was attended by 21 women of all ages (1570). The information collected based on interviews and statistical data highlighted current problems common among country women: loneliness, unemployment, lack of education, lack of financial means to undertake attempts to acquire new professional competences (e.g. Internet access), alcohol related diseases, depressive disorders, domestic violence, lack of financial means for private medical intervention in case of emergency or chronic conditions. Many of these problems remain unresolved due to the misconstrued/misevaluated sense of shame and social rejection that is deeply rooted in social awareness. The article discusses the importance of occupational therapy through art and to prove the advantages of introducing the language of abstraction as the most effective element of releasing emotions through the use of unconventional tools and the workshop. Using the language of abstraction not only improves the competences of participation in the perception of contemporary art, but, above all evokes the potential of creative energy, intensifies the process of creative and logical thinking, encourages reflection and provides satisfaction, thus increasing the self-esteem of the participants in art therapy.
K e y w o r d s:abstraction, art therapy, painting, countryside
PAIN TREATMENT IN STATIONARY PALLIATIVE CARE UNITS pełny artykuł (full article) - plik PDF
Małgorzata Pucułek*, Agnieszka Sikora-Wiórkowska**, Krzysztof Wiórkowski**, Michał Konopelko***, Ryszard Maciejewski*, Jakub Pawlikowski****
*Chair of Human Anatomy, Medical University in Lublin
** Students Scientific Society of Chair of Human Anatomy, Medical University in Lublin, Poland
*** Chair and Department of Hygiene, Medical University in Lublin
**** Department of Ethics and Human Philosophy, Medical University in Lublin
S u m m a r y. At the end of life oncological patients develop many problems due to altered organ functioning, which often leads to progressive multiorgan failure, loss of physiological needs, phasing out social life and altered state of consciousness. Both the patient and their family suffer. Symptomatic treatment is therefore a very important issue in palliative medicine, especially in relation to oncological care. The symptoms become more severe with the disease advancement. Primary symptom reported by oncological patients is pain that occurs regardless of the tumor location. The aim of this study is to present methods of efficient pain treatment in cancer patients applied in different settings of palliative care, i.e. hospital and hospice. The paper reviews literature on palliative care, including the recommendations of the European Association for Palliative Care, WHO. The Code of Medical Ethics and legal regulations oblige health care providers to ensure patient dignified and peaceful conditions of dying. Nowadays it is possible as there are many options, and lack of knowledge or prejudice cannot be an obstacle in bringing relief to terminally ill patients. Currently, many of these symptoms can be successfully managed to reduce the suffering of patients who cannot be expected to be cured.
K e y w o r d s: palliative care, hospice, pain, pain treatment
VIRUSES OF POLYOMAVIRUS FAMILY LIKE MCV, WUV AND KIV INVOLVED IN HUMAN DISEASES- pełny artykuł (full article) - plik PDF
Véronique Petit*, Konrad Rejdak*, Janusz Kocki**
* Department of Neurology, Medical University of Lublin, Poland
** Department of Clinical Genetics, Medical University of Lublin, Poland
S u m m a r y. Polyomaviruses are a family of small DNA viruses known to infect a wide range of vertebrates and invertebrates. Although polyomaviruses do not typically cause illness in healthy individuals, several polyomaviruses may result in catastrophic diseases in immunocompromised hosts. The article is a review of the reports available in PubMed on selected polyomavirus, i.e. Merkel cell polyomaviruses (MCV), Washington University virus (WUV) and Karolinska Institute viruses (KIV) involved in human diseases. Besides, MCV is likely to cause Merkell cell carcinoma. The viruses like WUV and KIV are also involved in the development of respiratory tract infections.
K e y w o r d s: DNA virus, polyomaviruses, Merkell cell polyomavirus, KI virus, WU virus
BIOCOMPATIBILITY AND BIOTOLERABILITY OF TITANIUM-BASED MATERIAL USED IN MEDICINE- pełny artykuł (full article) - plik PDF
Jan Sawicki*, Magdalena Wójciak-Kosior*, Michał Staniak*, Michał Latalski**, Mateusz Reda***, Ireneusz Sowa*
*Chair of Chemistry, Department of Analytical Chemistry, Medical University of Lublin.
**Children Orthopedic Department Medical University, Lublin.
Department of Clinical Genetics, Medical University of Lublin, Poland
S u m m a r y. Titanium is an extremely durable and chemically resistant metal. Due to its properties it is widely used in industry. Medical applications of Ti and Ti alloys are mainly focused on the use of rods, implants, plates, cages, valves and pins, even needles and stents. Those devices support the treatment of spinal curvature, reconstruction of bone tissue and ligaments or they shield the internal organs if natural protection is missing. The extensive use of titanium is related, among others, to its high biocompatibility.
The paper briefly discusses the characteristics of titanium and its alloys used in medicine
K e y w o r d s: titanium, biomaterials
BKV AND JCV VIRUSES OF POLYOMAVIRUS FAMILY INVOLVED IN HUMAN DISEASES- pełny artykuł (full article) - plik PDF
Véronique Petit*, Janusz Kocki**, Konrad Rejdak*
*Department of Neurology, Medical University of Lublin, Poland
**Department of Clinical Genetics, Medical University of Lublin, Poland
S u m m a r y. Infections with polyomaviruses are widespread. The number of identified polyomaviruses has grown radically over the last 10 years to more than 35 subtypes, including 13 typical of humans. The work is based on a review of the literature of the last 5 years available in PubMed, concerned with selected polyomaviruses involved in human diseases, e.g. nephritis caused by BK virus (BKV), or encephalitis caused by JC virus (JCV). Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the CNS.
K e y w o r d s: infection, polyomavirus, BK virus, JC virus, progressive multifocal leukoencephalopathy
MICROELEMENT STATUS IN RATS UNDER IODINE DEFICIENCY AND INSULIN RESISTANCE pełny artykuł (full article) - plik PDF
Iryna Hlozhyk, Tetyana Strokosh, Natalia Voronych-Semchenko
Department of Physiology, State Higher Educational Institution Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
S u m m a r y. Macro- and micronutrient status in animals with insulin resistance was studied and referred to proper and limited iodine supply. The analysis involved the reduction of magnesium, chromium content and the increase in iron and calcium content in the liver, reduction of copper, calcium and the increase in iron level in the erythrocyte mass in animals with insulin resistance and respective reference values in intact animals. The findings of the study carried out in rats with insulin resistance with underlying iodine deficiency included: reduced liver magnesium concentration compared to initial increase in iron and calcium, in the red blood cell mass the decrease in the concentration of copper, magnesium, zinc, and increased iron level compared to the initial values.
K e y w o r d s: insulin resistance, iodine deficiency, macro-, microelement status, liver, erythrocyte mass.
CHROMOLITH HPLC COLUMNS IN ANALYSIS OF PLASMA AND BLOOD SAMPLES - pełny artykuł (full article) - plik PDF
Michał Staniak, Ireneusz Sowa, Jan Sawicki, Janusz Polkowski,
Department of Analytical Chemistry, Medical University of Lublin, Lublin, Poland
S u m m a r y. Chromatography has a great importance in the analysis of drugs and their derivatives in samples of different origin. However, the investigation of samples such as blood or plasma is difficult because their complex matrix may clog the pores of adsorbent and spaces between sorbent particles, and it decreases column longevity. To minimalize these effects, monolithic adsorbents were introduced as an alternative to spherical stationary phases. The paper presents the application of silica based monolithic columns in the determination of drugs and their metabolites in human blood and plasma.
K e y w o r d s: high performance liquid chromato-graphy, monolithic column, Chromolith
COGNITIVE IMPAIRMENT IN PATIENTS WITH MULTIPLE SCLEROSIS : LITERATURE REVIEW - pełny artykuł (full article) - plik PDF
Aleksandra Marzęda*, Joanna Szkatuła*, Véronique Petit**, Janusz Kocki***,
Konrad Rejdak**
*Students Scientific Society of Neurology, Medical University of Lublin, Poland
**Department of Neurology, Medical University of Lublin, Poland
***Department of Clinical Genetics, Medical University of Lublin, Poland
S u m m a r y.Multiple sclerosis (MS) is most common immune-mediated inflammatory demyelinating disease of the central nervous system, which often causes progressive neurological disability. The paper reviews scientific reports on multiple sclerosis (MS) concerning cognitive impairment. Many patients with MS have or will develop some cognitive deficits. Progressive symptoms affect not only motor skills but also worsen activities of daily living and reduce independence. This part of MS clinical picture is better known due to neuropsychological research and neuroimaging. Cognitive behavioral therapy and education programs are promising psychosocial interventions to improve coping and lessen cognitive impairment.
K e y w o r d s: multiple sclerosis, cognitive impairment, cognition, neuropsychology
BRIEF OVERVIEW OF INSTRUMENTAL METHODS FOR DETERMINATION OF TRACE ELEMENTS IN BIOLOGICAL AND ENVIROMENTAL SAMPLES.
Part I: SPECTROSCOPIC TECHNIQUES - pełny artykuł (full article) - plik PDF
Wojciech Szwerc, Maciej Strzemski, Ryszard Kocjan, Ireneusz Sowa
Chair of Chemistry, Department of Analytical Chemistry, Medical University of Lublin, Poland
S u m m a r y. Elemental analysis is important from the point of view of human health. It may be helpful in diagnosis of different diseases because they are often related to disturbance in the physiological or toxic level of elements. However, the determination of metal ions in trace amount is difficult; therefore, analytical techniques are still being developed to cope with increasingly complicated analytical challenges. New modifications of the devices are carried out providing an opportunity of their wider application in many fields. In the present paper, the most common spectroscopic techniques applied in analysis of biological and environmental samples are described.
K e y w o r d s: spectroscopy, analytical technique, atomic emission spectrometry, atomic absorption spectrometry, X-ray fluorescence, biological samples, ions, elements, trace analysis
BRIEF OVERVIEW OF INSTRUMENTAL METHODS FOR DETERMINATION OF TRACE ELEMENTS IN BIOLOGICAL AND ENVIROMENTAL SAMPLES.
PART II: SEPARATION AND ELECTROANALYTICAL TECHNIQUES- pełny artykuł (full article) - plik PDF
Wojciech Szwerc, Maciej Strzemski, Ryszard Kocjan, Ireneusz Sowa
Chair of Chemistry, Department of Analytical Chemistry, Medical University of Lublin, Poland.
S u m m a r y. Spectroscopic techniques, especially atomic absorption spectrometry, are used most frequently for routine investigation of trace amounts of toxic and physiologically important elements in samples of different origin. However, in some cases, other techniques such as ion chromatography or electroanalytical techniques can be also successfully applied.
In the paper, we present a brief description of both techniques and examples of their application to determine low concentrations of analytes.
K e y w o r d s: analytical techniques, ion chromatography, voltammetry, biological samples, ions, elements, trace analysis
LIPID AND PROTEIN PEROXIDATION IN RATS WITH IODINE DEFICIENCY, INSULIN RESISTANCE AND IN TERMS OF THEIR COMBINATION - pełny artykuł (full article) - plik PDF
Sergiy Guranych, Iryna Sokyrko, Tetyana Guranych, Vasyl Stetsevyat
Department of Physiology, State Higher Educational Institution Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
S u m m a r y.The examination of lipid and protein peroxidation, antioxidant defense in rats with iodine deficiency (ID), insulin resistance (IR) and in terms of their combination was studied. It was noticed that ID causes activation of free radical oxidation of lipids. IR increasingly affects the peroxidation of proteins in examined tissues. In case of ID and IR combination, the activation of peroxidation against the background of significant inhibition of anti-radical protection was observed.
K e y w o r d s: iodine deficiency, insulin resistance, peroxidation, antiradical defense.
INTERRELATION OF INDICATORS OF THYROID STATUS AND IRON METABOLISM IN SCHOOLCHILDREN OF THE ENDEMIC REGION - pełny artykuł (full article) - plik PDF
Natalia Voronych-Semchenko, Ulyana Shalamay, Olga Zayats
Department of Physiology, State Higher Educational Institution Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
S u m m a r y.The indexes of thyroid status and iron metabolism in schoolchildren from endemic region were studied. The probability of thyroid dysfunction significantly increases in terms of combined iodine and iron deficiency. A strong correlation between thyroid homeostasis (data of free triiodothyronine and thyroxine, thyroid stimulating hormone of adenohypophysis in the blood serum, urinary iodine concentration) and hemoglobin content in capillary blood, serum iron, serum ferritin was found.
K e y w o r d s: thyroid status, latent iron deficiency, light iodine deficiency.
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